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Physical Pharmaceutics I (BP302T) – Important Questions, MCQ & Notes

B.Pharm 3rd semester, PCI syllabus. Unit-wise syllabus notes, the important questions asked in the exam pattern (Section A, B, C), 10 free MCQs a day on the site; model answers with key-point checking come with the ₹49 plan.

Physical Pharmaceutics I syllabus (BP302T), unit-wise

1. Unit 1 · Solubility of drugs

   Solubility expressions, solute–solvent interactions, ideal solubility parameters, solvation and association, factors influencing solubility, diffusion in biological systems. Solubility of gases in liquids and of liquids in liquids; Raoult's law, ideal and real solutions; partially miscible liquids, critical solution temperature; distribution law, its limitations and applications.

2. Unit 2 · States of matter & physicochemical properties

   Changes in state, latent heat, vapour pressure, sublimation, critical point, eutectic mixtures, gases, aerosols (inhalers), relative humidity, liquid crystals, glassy state, crystalline and amorphous solids, polymorphism. Refractive index, optical rotation, dielectric constant, dipole moment, dissociation constant: determination and applications.

3. Unit 3 · Surface and interfacial phenomenon

   Liquid interfaces, surface and interfacial tension, surface free energy and its measurement, spreading coefficient, adsorption at liquid interfaces, surface active agents, HLB scale, solubilisation, detergency, adsorption at solid interfaces.

4. Unit 4 · Complexation and protein binding

   Classification of complexes, applications, methods of analysis, protein binding, complexation and drug action, crystalline structure of complexes, thermodynamic treatment of stability constants.

5. Unit 5 · pH, buffers and isotonic solutions

   Sorensen's pH scale, pH determination (electrometric and colorimetric), buffer equation, buffer capacity, applications of buffers, buffers in pharmaceutical and biological systems, buffered isotonic solutions.

Physical Pharmaceutics I important questions

Questions in the university exam pattern for BP302T, grouped by unit. Practise writing them; model answers with key-point checking open with the ₹49 plan.

Unit 1: Solubility of drugs

• [10 marks] Explain the quantitative approach to the various factors influencing the solubility of drugs. State the Nernst Distribution Law and discuss its pharmaceutical applications and limitations.

Unit 2: States of matter & physicochemical properties

• [10 marks] Discuss the states of matter and the changes in the state of matter. Explain latent heats, vapour pressure and the Clausius-Clapeyron equation.

Unit 3: Surface and interfacial phenomenon

• [10 marks] Define surface and interfacial tension. Describe in detail the principle and working of the capillary rise method for the measurement of surface tension.

Unit 4: Complexation and protein binding

• [10 marks] Discuss protein binding of drugs: mechanism, factors affecting it, and its significance in drug action (complexation and drug action).

Unit 5: pH, buffers and isotonic solutions

• [10 marks] Define buffer capacity and derive the Henderson-Hasselbalch equation for a weak acid and its salt. Discuss the applications of buffers in pharmaceutical systems.

Physical Pharmaceutics I MCQ with answers

Sample model answers

How a good exam answer looks for Physical Pharmaceutics I (answers open with the ₹49 plan).