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Pharmaceutical Organic Chemistry II (BP301T) – Important Questions, MCQ & Notes

B.Pharm 3rd semester, PCI syllabus. Unit-wise syllabus notes, the important questions asked in the exam pattern (Section A, B, C), 10 free MCQs a day on the site; model answers with key-point checking come with the ₹49 plan.

Pharmaceutical Organic Chemistry II syllabus (BP301T), unit-wise

1. Unit 1 · Benzene and its derivatives

   Analytical, synthetic and other evidences for the structure of benzene; orbital picture; resonance; aromatic character and Hückel's rule. Reactions of benzene: nitration, sulphonation, halogenation, Friedel–Crafts alkylation (limitations) and acylation. Effect of substituents on reactivity and orientation in electrophilic substitution. Structure and uses of DDT, saccharin, BHC and chloramine.

2. Unit 2 · Phenols, aromatic amines and aromatic acids

   Phenols: acidity, effect of substituents on acidity, qualitative tests; structure and uses of phenol, cresols, resorcinol, naphthols. Aromatic amines: basicity, effect of substituents on basicity, synthetic uses of aryl diazonium salts. Aromatic acids: acidity, effect of substituents, important reactions of benzoic acid.

3. Unit 3 · Fats and oils

   Fatty acids and their reactions; hydrolysis, hydrogenation, saponification, rancidity of oils, drying oils. Analytical constants: acid value, saponification value, ester value, iodine value, acetyl value, Reichert–Meissl (RM) value: significance and principle of determination.

4. Unit 4 · Polynuclear hydrocarbons

   Synthesis and reactions; structure and medicinal uses of naphthalene, phenanthrene, anthracene, diphenylmethane, triphenylmethane and their derivatives.

5. Unit 5 · Cycloalkanes

   Stabilities: Baeyer's strain theory and its limitations, Coulson and Moffitt's modification, Sachse–Mohr theory (strainless rings). Reactions of cyclopropane and cyclobutane only.

Pharmaceutical Organic Chemistry II important questions

Questions in the university exam pattern for BP301T, grouped by unit. Practise writing them; model answers with key-point checking open with the ₹49 plan.

Unit 1: Benzene and its derivatives

• [10 marks] Why is benzene aromatic? Explain Huckel's rule with examples of aromatic, antiaromatic and non-aromatic compounds.

Unit 2: Phenols, aromatic amines and aromatic acids

• [10 marks] Discuss the acidity of phenols. Compare it with alcohols and carboxylic acids, explain the effect of substituents on acidity, and give the qualitative tests for phenols.

Unit 3: Fats and oils

• [10 marks] Write a note on rancidity and hydrogenation of oils. Explain the principle and significance of acid value, saponification value and iodine value.

Unit 4: Polynuclear hydrocarbons

• [10 marks] Define polynuclear hydrocarbons. Explain the Haworth synthesis, structure, reactions and medicinal uses of naphthalene and anthracene.

Unit 5: Cycloalkanes

• [10 marks] Explain Baeyer's strain theory. Calculate the angle strain in different cycloalkanes and discuss the limitations of the theory.

Pharmaceutical Organic Chemistry II MCQ with answers

Sample model answers

How a good exam answer looks for Pharmaceutical Organic Chemistry II (answers open with the ₹49 plan).